Microglial ER stress response via IRE1α regulates diet-induced metabolic imbalance and obesity in mice

L. Stilgenbauer, Q. Chen, D. Pungi, N. James, H. Jayarathne, L. Koshko, S. Scofield, K. Zhang, M. Sadagurski

Molecular Metabolism, 2025

Liver injury severity determines skeletal deterioration: a shared pathophysiological axis between MASLD and osteoarthritis.

M. del Río-Moreno, S. Poudel, L. Stilgenbauer, J. Córdoba-Chacón, Marianna Sadagurski, R. Kineman, S. Yakar

GeroScience, 2025

Integrative multi-omics analysis of metabolic dysregulation induced by occupational benzene exposure in mice.

S. Scofield, L. Koshko, L. Stilgenbauer, Alix Booms, Roxanne Bérubé, Christopher Kassotis, Chung-Ho Lin, Hyejeong Jang, Seongho Kim, Paul Stemmer, Adelheid Lempradl, Marianna Sadagurski

Science of the Total Environment, 2025

Canagliflozin reprograms the aging hippocampus in genetically diverse UM-HET3 mice and attenuates Alzheimer’s-like pathology

Hashan Jayarathne, Dulmalika Herath Manchanayake, Nina Chimienti, Omar Kadri, Katherine Gurdziel, Seongho Kim, Hyejeong Jang, Brett C. Ginsburg, Richard T. Miller, S. Yakar, M. Sadagurski

bioRxiv, 2025

The impact of inactivation of the GH/IGF axis during aging on healthspan.

S. Poudel, Ryan R Ruff, Zhiming He, Manisha Dixit, Godze Yildirim, Hashan Jayarathne, Dulmalika Herath Manchanayake, J. Basta‐Pljakic, Silvana Duran-Ortiz, Mitchell B. Schaffler, J. Kopchick, Marianna Sadagurski, S. Yakar

GeroScience, 2024

The Fourth Annual Symposium of the Midwest Aging Consortium

Jinoh Kim, Rochelle Buffenstein, A. Bronikowski, Natalia-Del Pilar Vanegas, Lorena Rosas, Paula Agudelo-Garcia, Ana L Mora, Mauricio Rojas, Davis A Englund, Nathan K. LeBrasseur, Allancer D C Nunes, Paul D. Robbins, Marian L Kohut, Siddhant Kothadiya, Rizia Bardhan, Christina Camell, Ines Sturmlechner, Jörg J. Goronzy, Chung-Yang Yeh, D. Lamming, Shijiao Huang, S. Leiser, Wilber Escorcia, Matthew S Gill, Jackson R. Taylor, S. Helfand, Sovannarith Korm, K. Gribble, Mariana Pehar, Magdalena Blaszkiewicz, Kristy L Townsend, Eric R. McGregor, Rozalyn M. Anderson, L. Stilgenbauer, Marianna Sadagurski, Alicia Taylor, Elizabeth McNeill, Thomas Stoeger, Hua Bai

The journals of gerontology. Series A, Biological sciences and medical sciences, 2024

Selective (α)-l-Rhamnosylation and Neuroprotective Activity Exploration of Cardiotonic Steroids.

Ryan Rutkoski, L. Debarba, L. Stilgenbauer, Tay Rosenthal, M. Sadagurski, P. Nagorny

ACS Medicinal Chemistry Letters, 2024

Microglia Mediate Metabolic Dysfunction From Common Air Pollutants Through NF-κB Signaling

L. Debarba, Hashan Jayarathne, L. Stilgenbauer, Ana L Terra Dos Santos, L. Koshko, S. Scofield, R. Sullivan, A. Mandal, U. Klueh, M. Sadagurski

Diabetes, 2024

Canagliflozin treatment prevents follicular exhaustion and attenuates hallmarks of ovarian aging in genetically heterogenous mice.

J. Isola, Subhasri Biswas, Hashan Jayarathne, Chase R Hubbart, Jéssica D Hense, Satoshi Matsuzaki, Michael T. Kinter, Kenneth M. Humphries, Sarah R. Ocañas, Marianna Sadagurski, Michael B. Stout

GeroScience, 2024

Hypothalamic sex-specific metabolic shift by canagliflozin during aging

Hashan S. M. Jayarathne, Ryan Sullivan, Lukas Stilgenbauer, Lucas K. Debarba, Artur Kuchumov, Lisa Koshko, Sydney Scofield, Wanqing Liu, Brett C. Ginsburg, Richard A. Miller, Marianna Sadagurski

GeroScience, vol. 46, 2024 May, pp. 4479--4493

Repurposing Canagliflozin to target brain aging

Hashan Jayarathne, Wanqing Liu, M. Sadagurski

Aging, 2023

Prenatal benzene exposure in mice alters offspring hypothalamic development predisposing to metabolic disease in later life.

L. Koshko, S. Scofield, L. Debarba, L. Stilgenbauer, P. Fakhoury, Hashan Jayarathne, J. E. Pérez-Mojica, E. Griggs, Adelheid Lempradl, M. Sadagurski

Chemosphere, 2023

Mast Cell Deficiency in Mice Attenuates Insulin Phenolic Preservative-Induced Inflammation

Shereen Kesserwan, M. Sadagurski, Limin Mao, U. Klueh

Biomedicines, 2023

Intrinsic sexual dimorphism in the placenta determines the differential response to benzene exposure

A. Maxwell, Nicholas K Adzibolosu, Anna Hu, Y. You, P. Stemmer, D. Ruden, M. Petriello, M. Sadagurski, L. Debarba, L. Koshko, J. Ramadoss, A. Nguyen, Darby Richards, A. Liao, G. Mor, Jiahui Ding

iScience, 2023

Growth hormone receptor (GHR) in AgRP neurons regulates thermogenesis in a sex-specific manner

L. Stilgenbauer, J. M. D. de Lima, L. Debarba, Manal Khan, L. Koshko, J. Kopchick, A. Bartke, A. Schneider, M. Sadagurski

GeroScience, 2023

Efficient SABRE-SHEATH Hyperpolarization of Potent Branched-Chain-Amino-Acid Metabolic Probe [1-13C]ketoisocaproate

Isaiah Adelabu, Md Raduanul H Chowdhury, Shiraz Nantogma, Clementinah Oladun, Firoz Ahmed, L. Stilgenbauer, M. Sadagurski, T. Theis, B. Goodson, E. Chekmenev

Metabolites, 2023

Editorial: Environmental toxicity in reproduction

Jiahui Ding, Yong Song, Chunyan Liu, Marianna Sadagurski

Frontiers in Physiology, 2023

Editorial: Environmental stressors and metabolic disease

Kezhong Zhang, Cuiqing Liu, Marianna Sadagurski, Qinghua Sun

Frontiers in Endocrinology, 2023

Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice

Jessica M. Snyder, Kerriann M. Casey, Andrzej Galecki, David E. Harrison, Hashan Jayarathne, Navasuja Kumar, Francesca Macchiarini, Nadia Rosenthal, Marianna Sadagurski, Adam B. Salmon, Randy Strong, Richard A. Miller, Warren Ladiges

GeroScience, vol. 45, 2023 Feb, pp. 385--397

The Novel Peptide Chm-273s Has Therapeutic Potential for Metabolic Disorders: Evidence from In Vitro Studies and High-Sucrose Diet and High-Fat Diet Rodent Models

N. Mitkin, Vsevolod V. Pavshintcev, I. Sukhanova, I. Doronin, G. Babkin, M. Sadagurski, A. Malyshev

Pharmaceutics, 2022

Prenatal Pollutant Exposures and Hypothalamic Development: Early Life Disruption of Metabolic Programming

L. Koshko, S. Scofield, G. Mor, M. Sadagurski

Frontiers in Endocrinology, 2022

17-a-estradiol has sex-specific effects on neuroinflammation that are partly reversed by gonadectomy.

L. Debarba, Hashan Jayarathne, Richard A. Miller, M. Garratt, M. Sadagurski

The journals of gerontology. Series A, Biological sciences and medical sciences, 2022

Neuroprotective effects of Canagliflozin: Lessons from aged genetically diverse UM‐HET3 mice

Hashan S. M. Jayarathne, Lucas K. Debarba, Jacob J. Jaboro, Brett C. Ginsburg, Richard A. Miller, Marianna Sadagurski

Aging Cell, vol. 21, 2022 Jul, pp. e13653

In Utero Maternal Benzene Exposure Predisposes to the Metabolic Imbalance in the Offspring.

L. Koshko, L. Debarba, Mikaela Sacla, J. M. D. de Lima, O. Didyuk, P. Fakhoury, M. Sadagurski

Toxicological Sciences, 2021

Hypothalamic GHR—SIRT1 Axis in Fasting

J. M. D. de Lima, Chidera Ubah, L. Debarba, Iven Ayyar, O. Didyuk, M. Sadagurski

Cells, 2021

ARCGHR Neurons Regulate Muscle Glucose Uptake

J. M. D. de Lima, L. Debarba, Alan C. Rupp, Nathan R. Qi, Chidera Ubah, Manal Khan, O. Didyuk, Iven Ayyar, M. Koch, D. Sandoval, M. Sadagurski

Cells, 2021

Sex hormones underlying 17a-Estradiol effects on neuroinflammation

L. Debarba, Hashan Jayarathne, Richard A. Miller, M. Garratt, M. Sadagurski

bioRxiv, 2020

Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance

Amy K. Sutton, Ian E Gonzalez, M. Sadagurski, Michael W. Rajala, Chunxia Lu, Margaret B. Allison, Jessica M. Adams, M. Myers, M. White, D. Olson

Scientific Reports, 2020

Metabolic Reprogramming by In Utero Maternal Benzene Exposure

L. Koshko, L. Debarba, Mikaela Sacla, J. M. D. de Lima, O. Didyuk, P. Fakhoury, M. Sadagurski

bioRxiv, 2020

Growth hormone receptor (GHR)-expressing neurons in the hypothalamic arcuate nucleus regulate glucose metabolism and energy homeostasis

J. M. D. de Lima, L. Debarba, Manal Khan, Chidera Ubah, O. Didyuk, Iven Ayyar, M. Koch, M. Sadagurski

bioRxiv, 2020

Canagliflozin extends life span in genetically heterogeneous male but not female mice

Richard A. Miller, David E. Harrison, David B. Allison, M. Bogue, L. Debarba, Vivian Diaz, Elizabeth Fernandez, A. Galecki, W. Garvey, Hashan Jayarathne, Navasuja Kumar, M. Javors, Warren C. Ladiges, F. Macchiarini, James F. Nelson, P. Reifsnyder, Nadia Rosenthal, M. Sadagurski, Adam B Salmon, Daniel L. Smith, Jessica M. Snyder, David B. Lombard, R. Strong

JCI Insight, 2020

Acarbose protects from central and peripheral metabolic imbalance induced by benzene exposure

L. Debarba, A. Mulka, J.B.M. Lima, O. Didyuk, P. Fakhoury, L. Koshko, A. Awada, K. Zhang, U. Klueh, M. Sadagurski

Brain, behavior, and immunity, 2020

Sexual dimorphism in hypothalamic inflammation in the offspring of dams exposed to diet rich in high fat and branched chain amino acids.

M. Sadagurski, L. Debarba, J. Werneck-de-Castro, Abear Ali Awada, Tess A. Baker, E. Bernal-Mizrachi

American Journal of Physiology. Endocrinology and Metabolism, 2019

SAT-179 Low Grade Benzene Exposure Induces Metabolic Dysbalance and Hypothalamic Inflammation in Mice

L. Debarba, A. Mulka, A. Awada, O. Didyuk, D. Marcus, U. Klueh, M. Sadagurski

Journal of the Endocrine Society, 2019

Targeting neuroinflammation - a potential for anti-aging interventions

Gillian Cady, M. Sadagurski

Aging, 2017

Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons

Gillian Cady, Taylor Landeryou, M. Garratt, J. Kopchick, Nathan R. Qi, D. Garcia-Galiano, C. Elias, M. Myers, Richard A. Miller, D. Sandoval, M. Sadagurski

Molecular Metabolism, 2017

Anti‐aging drugs reduce hypothalamic inflammation in a sex‐specific manner

M. Sadagurski, Gillian Cady, Richard A. Miller

Aging Cell, 2017

Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice.

A. Kuznetsova, Yue Yu, J. Hollister-Lock, Lynn M Opare-Addo, A. Rozzo, M. Sadagurski, L. Norquay, Jessica E. Reed, Ilham El Khattabi, S. Bonner-Weir, G. Weir, Arun J Sharma, M. White

JCI Insight, 2016

Transient early food restriction leads to hypothalamic changes in the long-lived crowded litter female mice

M. Sadagurski, Taylor Landeryou, Gillian Cady, A. Bartke, E. Bernal-Mizrachi, Richard A. Miller

Physiological Reports, 2015

Growth hormone modulates hypothalamic inflammation in long‐lived pituitary dwarf mice

M. Sadagurski, Taylor Landeryou, Gillian Cady, J. Kopchick, E. List, D. Berryman, A. Bartke, Richard A. Miller

Aging Cell, 2015

Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis.

M. Sadagurski, Taylor Landeryou, M. Blandino-Rosano, Gillian Cady, L. Elghazi, D. Meister, Lauren See, A. Bartke, E. Bernal-Mizrachi, Richard A. Miller

American Journal of Physiology. Endocrinology and Metabolism, 2014

Differential Effects of Delayed Aging on Phenotype and Striatal Pathology in a Murine Model of Huntington Disease

S. Tallaksen-Greene, M. Sadagurski, Li Zeng, R. Mauch, Matthew Perkins, V. Banduseela, A. Lieberman, Richard A. Miller, H. Paulson, R. Albin

Journal of Neuroscience, 2014

Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis

M. Sadagurski, X. Dong, M. Myers, M. White

Molecular Metabolism, 2013

Integrating metabolism and longevity through insulin and IGF1 signaling.

M. Sadagurski, M. White

Endocrinology and metabolism clinics of North America (Print), 2013

IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action.

M. Sadagurski, R. Leshan, C. Patterson, A. Rozzo, A. Kuznetsova, J. Skorupski, Justin C. Jones, R. DePinho, M. Myers, M. White

Cell Metabolism, 2012

IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease.

M. Sadagurski, Zhiyong Cheng, A. Rozzo, Isabella Palazzolo, Gregory R. Kelley, X. Dong, D. Krainc, M. White

Journal of Clinical Investigation, 2011

Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3β?

Rosemarie M. Carew, M. Sadagurski, R. Goldschmeding, F. Martin, M. White, D. Brazil

BMC Developmental Biology, 2010

Human IL6 enhances leptin action in mice

M. Sadagurski, L. Norquay, J. Farhang, K. D’Aquino, Kyle D. Copps, M. White

Diabetologia, 2009

Insulin receptor substrate 1 (IRS‐1) plays a unique role in normal epidermal physiology

M. Sadagurski, S. Nofech-Mozes, G. Weingarten, M. White, T. Kadowaki, E. Wertheimer

Journal of Cellular Physiology, 2007

Insulin-Like Growth Factor 1 Receptor Signaling Regulates Skin Development and Inhibits Skin Keratinocyte Differentiation

M. Sadagurski, S. Yakar, G. Weingarten, M. Holzenberger, C. Rhodes, D. Breitkreutz, D. Leroith, E. Wertheimer

Molecular and Cellular Biology, 2006

Insulin Receptor Substrate 2 Plays Diverse Cell-specific Roles in the Regulation of Glucose Transport*

M. Sadagurski, G. Weingarten, C. Rhodes, M. White, E. Wertheimer

Journal of Biological Chemistry, 2005